HELLO DNA,
DON’T WORRY, I MADE IT
HOME TO MOM & DAD!

BREAKS IN DNA STRANDS = NO GENETIC MATERIAL TRANSPORT

During cell division, DNA is transferred to each new cell just like a train transfers cargo to a destination. If a train’s tracks are damaged, the train cannot make it to the destination. The same is true when DNA strands are damaged. Both the train and the DNA are derailed.

If there are serious breaks in the DNA (genetic information is “broken”, “damaged”), new cells will be incomplete and unable to continue the cell division process. Embryonic development stops.

During cell division, DNA is transferred to each new cell just like a train transfers cargo to a destination. If a train’s tracks are damaged, the train cannot make it to the destination. The same is true when DNA strands are damaged. Both the train and the DNA are derailed.

If there are serious breaks in the DNA (genetic information is “broken”, “damaged”), new cells will be incomplete and unable to continue the cell division process. Embryonic development stops.

Sperm repair

Source: Sedo C.A. et al.; JBRA Assist Reprod. 2017;21(4):343-350.

SPERM CELLS
CANNOT REPAIR THEMSELVES

Sperm repair
Sperm repair

The sole task of the sperm cell is to safely transport genetic information package (DNA) into the egg cell. Because sperm cells cannot repair themselves, the more breaks are present in a sperm cell’s DNA, the more vulnerable the genetic information package is overall, making it difficult for the sperm cell to complete its task.

DNA breaks can affect sperm shape.

Source: Cohen-Bacrie P. et al; Fertility & Sterility 2009, 19(5): 1801-1805.

DNA strand
DNA strand

Different Testing procedures are available for detecting DNA breaks (fragmentation rate) in Spermien. As a Standard, however, all fathers-to-be 35+ are recommended to take PROFERTIL® due to the escalated incidence of DNA fragmentation above the age of 35.

Different Testing procedures are available for detecting DNA breaks (fragmentation rate) in Spermien. As a Standard, however, all fathers-to-be 35+ are recommended to take PROFERTIL® due to the escalated incidence of DNA fragmentation over the age of 35.

It is now known that male infertility goes hand-in-hand with damaged genetic material. More cells with damaged DNA means more damaged genetic material. More damaged genetic material means lower chances for successful pregnancy.

It is now known that male infertility goes hand-in-hand with damaged genetic material. More cells with damaged DNA means more damaged genetic material. More damaged genetic material means lower chances for successful pregnancy.

Sources:
Cohen-Bacrie P. et al.; Fertility and Sterility 2009;91(5):1801-5.
Sartorius G.A. et al.; Human Reprod. 2010;16(1):65-79.
Plastira K. et al.; J Assist Reprod Genet. 2007;24(10): 437-443.

SUPPORTS THE
JOURNEY TO PREGNANCY

play_arrow Reduction of sperm DNA-breakage

play_arrow Less abnormally-shaped sperm

PROFERTIL®’s ability to protect DNA against damage has been proven in 2 clinical studies. After 3 months of taking PROFERTIL®, 74,6% of patients’ test results showed a major decrease of damaged sperm DNA and a significant increase of healthy, undamaged sperm DNA.

PROFERTIL®’s ability to protect DNA against damage has been proven in 2 clinical studies. After 3 months of taking PROFERTIL®, 74,6% of patients’ test results showed a major decrease of damaged sperm DNA and a significant increase of healthy, undamaged sperm DNA.

Reduces sperm DNA-breakage
Reduces sperm DNA-breakage

Sources:
Lipovac M. et al.; EMJ Urol. 2014;1:60-65.
Eidenberger F. et al.; Fertility & Reproduction 2019; 1:136-140. First results presented by Prof. Dr. Martin Imhof at Aspire 2019.

Sperm repair

Sperm repair

Sperm repair

Sperm repair

Sperm repair

Sperm repair