HELLO DNA,
DON’T WORRY, I MADE IT
HOME TO MOM & DAD!

BREAKS IN DNA STRANDS = NO GENETIC MATERIAL TRANSPORT

During cell division, DNA is transferred to each new cell just like a train transfers cargo to a destination. If a train’s tracks are damaged, the train cannot make it to the destination. The same is true when DNA strands are damaged. Both the train and the DNA are derailed.

If there are serious breaks in the DNA (genetic information is “broken”, “damaged”), new cells will be incomplete and unable to continue the cell division process. Embryonic development stops.

The chances for a successful natural or in-vitro conception decrease. The risk of a miscarriage is increased.

Did you know that DNA-breaks in sperm …

… are related to the risk of miscarriage?

> FIND OUT MORE

During cell division, DNA is transferred to each new cell just like a train transfers cargo to a destination. If a train’s tracks are damaged, the train cannot make it to the destination. The same is true when DNA strands are damaged. Both the train and the DNA are derailed.

If there are serious breaks in the DNA (genetic information is “broken”, “damaged”), new cells will be incomplete and unable to continue the cell division process. Embryonic development stops.

The chances for a successful natural or in-vitro conception decrease. The risk of a miscarriage is increased.

Quelle: Sedo C.A. et al.; JBRA Assist Reprod. 2017;21(4):343-350.

SPERM CELLS
CANNOT REPAIR THEMSELVES

The task of a sperm cell is to transport the hereditary information (DNA) safely packaged into the egg cell. The more breaks there are in the DNA structure itself, the more difficult it is for the sperm to do its job.

Source: Cohen-Bacrie P. et al; Fertility & Sterility 2009, 19(5): 1801-1805.

DNA strand
DNA strand

Different Testing procedures are available for detecting DNA breaks (fragmentation rate) in Spermien. As a Standard, however, all fathers-to-be 35+ are recommended to take PROFERTIL® due to the escalated incidence of DNA fragmentation above the age of 35.

Different Testing procedures are available for detecting DNA breaks (fragmentation rate) in Spermien. As a Standard, however, all fathers-to-be 35+ are recommended to take PROFERTIL® due to the escalated incidence of DNA fragmentation over the age of 35.

It is now known that male infertility goes hand-in-hand with damaged genetic material. More cells with damaged DNA means more damaged genetic material. More damaged genetic material means lower chances for successful pregnancy.

It is now known that male infertility goes hand-in-hand with damaged genetic material. More cells with damaged DNA means more damaged genetic material. More damaged genetic material means lower chances for successful pregnancy.

Sources:
Cohen-Bacrie P. et al.; Fertility and Sterility 2009;91(5):1801-5.
Sartorius G.A. et al.; Human Reprod. 2010;16(1):65-79.
Plastira K. et al.; J Assist Reprod Genet. 2007;24(10): 437-443.

SUPPORTS THE
JOURNEY TO PREGNANCY

Double-proven Positive Effect on Sperm DNA

play_arrow Reduction of sperm DNA-breakage

play_arrow Less abnormally-shaped sperm

PROFERTIL®’s ability to protect DNA against damage has been proven in 2 clinical studies. After 3 months of taking PROFERTIL®, 74,6% of patients’ test results showed a major decrease of damaged sperm DNA and a significant increase of healthy, undamaged sperm DNA.

PROFERTIL®’s ability to protect DNA against damage has been proven in 2 clinical studies. After 3 months of taking PROFERTIL®, 74,6% of patients’ test results showed a major decrease of damaged sperm DNA and a significant increase of healthy, undamaged sperm DNA.

Reduces sperm DNA-breakage

Sources:
Lipovac M. et al.; EMJ Urol. 2014;1:60-65.
Lipovac M. et. al.; Gynecological Endocrinology 2021 Jun; 37(6).

Sperm DNA Fragmentation and Miscarriage – Dr. Helena Lim Yun Hsuen